Catalog No.: PC-47113Not For Human Use, Lab Use Only.
TZB-30878 is a potent, selective, orally bioavailable 5-HT1A agonist and 5-HT3 antagonist, selectively binds to human 5-HT1A and 5-HT) receptors with Kd values of 0.68 and 8.90 nM, respectively.
TZB-30878 is a potent, selective, orally bioavailable 5-HT1A agonist and 5-HT3 antagonist, selectively binds to human 5-HT1A and 5-HT) receptors with Kd values of 0.68 and 8.90 nM, respectively.
Systemic administration of TZB-30878 inhibited 5-HT-induced bradycardia in a dose-dependent manner in rats, TZB-30878 produced signs of 5-HT syndrome in rats in behavioral assays.
TZB-30878 (1-10 mg/kg p.o.) normalized stress-induced defecation in a dose-dependent manner in IBS-like model in rats.
