Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.

You are here:Home-Chemical Inhibitors & Agonists-GPCR-5-HT Receptor-TZB-30878
TZB-30878

Chemical Structure : TZB-30878

CAS No.: 864385-95-5

TZB-30878 (TZB30878)

Catalog No.: PC-47113Not For Human Use, Lab Use Only.

TZB-30878 is a potent, selective, orally bioavailable 5-HT1A agonist and 5-HT3 antagonist, selectively binds to human 5-HT1A and 5-HT) receptors with Kd values of 0.68 and 8.90 nM, respectively.

Packing Price Stock Quantity
25 mg Get quote
50 mg Get quote
100 mg Get quote

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    TZB-30878 is a potent, selective, orally bioavailable 5-HT1A agonist and 5-HT3 antagonist, selectively binds to human 5-HT1A and 5-HT) receptors with Kd values of 0.68 and 8.90 nM, respectively.
    Systemic administration of TZB-30878 inhibited 5-HT-induced bradycardia in a dose-dependent manner in rats, TZB-30878 produced signs of 5-HT syndrome in rats in behavioral assays.
    TZB-30878 (1-10 mg/kg p.o.) normalized stress-induced defecation in a dose-dependent manner in IBS-like model in rats.

    Physicochemical Properties

    M.Wt 432.572
    Formula C25H32N6O
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    3-Amino-5,6,7,8-tetrahydro-2-[4-[4-(quinolin-2-yl)piperazin-1-yl]butyl]quinazolin-4(3H)-one

    References

    1. Tamaoki S, et al. J Pharmacol Exp Ther. 2007 Sep;322(3):1315-23.

    2. Asagarasu A, et al. J Med Chem. 2010 Nov 11;53(21):7549-63.

    Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

    Contact Us sales@probechem.com

    Bulk Inquiry

    * Indicates a Required FieldYour information is safe with us.

    • *Product name:
    • *Applicant name:
    • *Email address:
    • *Organization name:
    • *Requested quantity:
    • *Country:
    • *Additional Information:

    Get Quote

    * Indicates a Required FieldYour information is safe with us.

    • *Product name:
    • *Applicant name:
    • *Email address:
    • *Organization name:
    • *Requested quantity:
    • *Country:
    • Additional Information: