Catalog No.: PC-23876Not For Human Use, Lab Use Only.
Talazoparib (BMN-673) is a highly potent, selective PARP1/2 inhibitor (PARP1, IC50=0.57 nM), inhibits PARP1 and PARP2 to a similar extent with Ki of 1.20 and 0.85 nM, respectively.
Talazoparib (BMN-673) is a highly potent, selective PARP1/2 inhibitor (PARP1, IC50=0.57 nM), inhibits PARP1 and PARP2 to a similar extent with Ki of 1.20 and 0.85 nM, respectively.
Talazoparib (BMN-673) inhibits intracellular poly (ADP-ribose) (PAR) formation with an IC50 of 2.5 nM in LoVo cells to hydrogen peroxide (H2O2) to induce PAR synthesis.
Talazoparib (BMN-673) shows no effect on PARG activity as well as a protein panel.
Talazoparib (BMN-673) selectively targets tumor cells with BRCA1, BRCA2, or PTEN gene defects。
Talazoparib (BMN-673) elicited remarkable antitumor activity in vivo xenografted tumors that carry defects in DNA repair due to BRCA mutations or PTEN deficiency。
