Catalog No.: PC-23876Not For Human Use, Lab Use Only.
Talazoparib (MN 673) is a highly potent, selective PARP1/2 inhibitor (PARP1, IC50=0.57 nM), inhibits PARP1 and PARP2 to a similar extent with Ki of 1.20 and 0.85 nM, respectively.
Talazoparib (MN 673) is a highly potent, selective PARP1/2 inhibitor (PARP1, IC50=0.57 nM), inhibits PARP1 and PARP2 to a similar extent with Ki of 1.20 and 0.85 nM, respectively. Talazoparib (MN 673) inhibits intracellular poly (ADP-ribose) (PAR) formation with an IC50 of 2.5 nM in LoVo cells to hydrogen peroxide (H2O2) to induce PAR synthesis. Talazoparib (MN 673) shows no effect on PARG activity as well as a protein panel. Talazoparib (MN 673) selectively targets tumor cells with BRCA1, BRCA2, or PTEN gene defects。 Talazoparib (MN 673) elicited remarkable antitumor activity in vivo xenografted tumors that carry defects in DNA repair due to BRCA mutations or PTEN deficiency。
