Catalog No.: PC-21365Not For Human Use, Lab Use Only.
Talnetant (SB223412) is a potent, selective, competitive and brain-permeable neurokinin-3 receptor (NK3R) antagonist with Ki of 1.4 nM in hNK-3-CHO cells.
Talnetant (SB223412) is a potent, selective, competitive and brain-permeable neurokinin-3 receptor (NK3R) antagonist with Ki of 1.4 nM in hNK-3-CHO cells.
Talnetant (SB223412) displays >100-fold selectivity for hNK-3 relative to the hNK-2 receptor and has no affinity for hNK-1. Talnetant (SB223412) reduces the accumulation of NKB-induced IP in U-2OS cells expressing the human NK3 receptor.
Talnetant (SB223412) inhibit the miosis induced by senktide in a dose-dependent manner with an ED50 of 0.44mg/kg in conscious rabbits.
Talnetant (SB223412) significantly attenuate senktide-induced "wet dog wagging" behavior in a dose-dependent manner.
Talnetant (SB223412) significantly increase extracellular dopamine and norepinephrine in the medial prefrontal cortex and reduce haloperidol-induced increases in dopamine levels in the vomeronasal nucleus of freely moving guinea pigs.
