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Chemical Structure : Tamapin TFA
CAS No.:
Catalog No.: PC-21845Not For Human Use, Lab Use Only.
Tamapin TFA salt is a venom peptide from the Indian red scorpion (Mesobuthus tamulus), potent and selective inhibitor of small conductance calcium-activated potassium channel 2 (SK2, KCNN2) with IC50 of 24 pM.
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Tamapin TFA salt is a venom peptide from the Indian red scorpion (Mesobuthus tamulus), potent and selective inhibitor of small conductance calcium-activated potassium channel 2 (SK2, KCNN2) with IC50 of 24 pM.
Tamapin displays remarkable selectivity for SK2 versus SK1 ( approximately 1750-fold) and SK3 ( approximately 70-fold) channels.
Tamapin mitigates physiological abnormalities in reporter-positive neurons in PAE mice.
Tamapin improves impaired motor skill learning in PAE mice.
Tamapin reverses learning deficits in a mouse model of fetal alcohol spectrum disorders.
| M.Wt | 3458.11 (free base) | |
| Formula | C146H238N44O41S6.xC2HF3O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Ala-Phe-Cys-Asn-Leu-Arg-Arg-Cys-Glu-Leu-Ser-Cys-Arg-Ser-Leu-Gly-Leu-Leu-Gly-Lys-Cys-Ile-Gly-Glu-Glu-Cys-Lys-Cys-Val-Pro-Tyr-NH2 (Disulfide bridge: Cys3-Cys21, Cys8-Cys26, Cys12-Cys28) |
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1. Pedarzani P, et al. J Biol Chem. 2002 Nov 29;277(48):46101-9.
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