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Taprenepag isopropyl

Chemical Structure : Taprenepag isopropyl

CAS No.: 1005549-94-9

Taprenepag isopropyl (PF-04217329, PF04217329)

Catalog No.: PC-28387Not For Human Use, Lab Use Only.

Taprenepag isopropyl (PF-04217329) is the prodrug of Taprenepag (CP-544326), a potent and selective prostaglandin EP2 receptor agonist with IC50 of 10 nM and EC50 of 2.8 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Taprenepag isopropyl (PF-04217329) is the prodrug of Taprenepag (CP-544326), a potent and selective prostaglandin EP2 receptor agonist with IC50 of 10 nM and EC50 of 2.8 nM.
Taprenepag isopropyl (PF-04217329) shows increased corneal permeability and ocular bioavailability.
Taprenepag isopropyl (PF-04217329) causes sustained intraocular pressure (IOP) reduction, is a clinical candidate for treatment of glaucoma and ocular hypertension.

Physicochemical Properties

M.Wt 520.60
Formula C27H28N4O5S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

Isopropyl 2-(3-((N-(4-(1H-pyrazol-1-yl)benzyl)pyridine-3-sulfonamido)methyl)phenoxy)acetate

References

1. Prasanna G, et al. Exp Eye Res. 2011 Sep;93(3):256-64.

2. Schachar RA, et al. Curr Eye Res. 2011 Sep;36(9):809-17.

3. Qu C, et al. Sci Adv. 2021 Apr 2;7(14):eabf1268.

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