Tariquidar (XR9576) is a potent, specific P-gp inhibitor with Kd of 5.1 nM.
Tariquidar (XR9576) potentiates the cytotoxicity of several drugs including doxorubicin, paclitaxel, etoposide, and vincristine in a panel of human MDR cell lines at 25-80 nM.
Tariquidar (XR9576) exhibits potent i.v. and p.o. activity without apparently enhancing the plasma pharmacokinetics of paclitaxel or the toxicity of coadministered drugs.
