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Chemical Structure : Tariquidar methanesulfonate hydrate
CAS No.: 625375-83-9
Catalog No.: PC-42649Not For Human Use, Lab Use Only.
A potent, specific P-gp inhibitor with Kd of 5.1 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 50 mg | $252 | In stock | |
| 100 mg | $396 | In stock | |
| 250 mg | Get quote |
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A potent, specific P-gp inhibitor with Kd of 5.1 nM; potentiates the cytotoxicity of several drugs including doxorubicin, paclitaxel, etoposide, and vincristine in a panel of human MDR cell lines at 25-80 nM; exhibits potent i.v. and p.o. activity without apparently enhancing the plasma pharmacokinetics of paclitaxel or the toxicity of coadministered drugs.
Breast Cancer
Phase 2 Discontinued
| M.Wt | 892.9887 | |
| Formula | C40H52N4O15S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 296 mg/mL; H2O: < 8.9 mg/mL |
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| Chemical Name/SMILES |
3-Quinolinecarboxamide, N-[2-[[[4-[2-(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]amino]carbonyl]-4,5-dimethoxyphenyl]-, methanesulfonate, hydrate (1:2:3) |
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1. Martin C, et al. Br J Pharmacol. 1999 Sep;128(2):403-11.
2. Mistry P, et al. Cancer Res. 2001 Jan 15;61(2):749-58.
3. Walker J, et al. Eur J Cancer. 2004 Mar;40(4):594-605.
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