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Tariquidar methanesulfonate hydrate

Chemical Structure : Tariquidar methanesulfonate hydrate

CAS No.: 625375-83-9

Tariquidar methanesulfonate hydrate (XR-9576, XR9576)

Catalog No.: PC-42649Not For Human Use, Lab Use Only.

Tariquidar methanesulfonate hydrate (XR9576) is a potent, specific P-gp inhibitor with Kd of 5.1 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Tariquidar methanesulfonate hydrate (XR9576) is a potent, specific P-gp inhibitor with Kd of 5.1 nM.
Tariquidar potentiates the cytotoxicity of several drugs including doxorubicin, paclitaxel, etoposide, and vincristine in a panel of human MDR cell lines at 25-80 nM.
Tariquidar exhibits potent i.v. and p.o. activity without apparently enhancing the plasma pharmacokinetics of paclitaxel or the toxicity of coadministered drugs.

Physicochemical Properties

M.Wt 892.9887
Formula C40H52N4O15S2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 296 mg/mL; H2O: < 8.9 mg/mL

Chemical Name/SMILES

3-Quinolinecarboxamide, N-[2-[[[4-[2-(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]amino]carbonyl]-4,5-dimethoxyphenyl]-, methanesulfonate, hydrate (1:2:3)

References

1. Martin C, et al. Br J Pharmacol. 1999 Sep;128(2):403-11.

2. Mistry P, et al. Cancer Res. 2001 Jan 15;61(2):749-58.

3. Walker J, et al. Eur J Cancer. 2004 Mar;40(4):594-605.

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