Catalog No.: PC-47093Not For Human Use, Lab Use Only.
Tasipimidine is a potent, selective and orally active human α2A-adrenoceptor agonist with pEC50 of 7.57, >100-fold selectivity over α2B-and α2C-adrenoceptors and the rodent α2D-adrenoceptor.
Tasipimidine is a potent, selective and orally active human α2A-adrenoceptor agonist with pEC50 of 7.57, >100-fold selectivity over α2B-and α2C-adrenoceptors and the rodent α2D-adrenoceptor.
Tasipimidine had no functional effects in the LNCaP cells expressing endogenously the human α1A-adrenoceptors but was a weak agonist in the Chem-1 cells coexpressing Gα15 protein and α1A-adrenoceptors.
Tasipimidine was a full agonist in the intracellular [Ca2+] assay, and a weak partial agonist in the inositol monophosphate accumulation assay.
Tasipimidine prolonged ejaculation latency and the interintromission interval at the dose of 200 µg/kg in the control of ejaculation and sexual incentive motivation in rats.
