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Chemical Structure : Tasipimidine
Catalog No.: PC-47093Not For Human Use, Lab Use Only.
Tasipimidine is a potent, selective and orally active human α2A-adrenoceptor agonist with pEC50 of 7.57, >100-fold selectivity over α2B-and α2C-adrenoceptors and the rodent α2D-adrenoceptor.
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Tasipimidine is a potent, selective and orally active human α2A-adrenoceptor agonist with pEC50 of 7.57, >100-fold selectivity over α2B-and α2C-adrenoceptors and the rodent α2D-adrenoceptor.
Tasipimidine had no functional effects in the LNCaP cells expressing endogenously the human α1A-adrenoceptors but was a weak agonist in the Chem-1 cells coexpressing Gα15 protein and α1A-adrenoceptors.
Tasipimidine was a full agonist in the intracellular [Ca2+] assay, and a weak partial agonist in the inositol monophosphate accumulation assay.
Tasipimidine prolonged ejaculation latency and the interintromission interval at the dose of 200 µg/kg in the control of ejaculation and sexual incentive motivation in rats.
| M.Wt | 232.283 | |
| Formula | C13H16N2O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Lehtimäki J, et al. Eur J Pharmacol. 2022 May 15;923:174949.
2. Lehtimäki J, et al. J Sex Med. 2021 Oct;18(10):1677-1689.
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