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Chemical Structure : Tasisulam
CAS No.: 519055-62-0
Catalog No.: PC-62313Not For Human Use, Lab Use Only.
Tasisulam (LY 573636) is a small molecule antitumor agent that induces apoptosis via the intrinsic pathway, resulting in cytochrome c release and caspase-dependent cell death.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $128 | In stock | |
| 50 mg | $198 | In stock | |
| 100 mg | $328 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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Tasisulam (LY-573636) is a small molecule antitumor agent that induces apoptosis via the intrinsic pathway, resulting in cytochrome c release and caspase-dependent cell death.
Tasisulam (LY-573636) shows antiproliferative effect against a variety of human hematopoietic malignancies, including AML, B-ALL, large B-cell and mantle cell lymphoma cell lines.
Tasisulam (LY-573636) promotes the recruitment of RBM39 to the CUL4-DCAF15 E3 ubiquitin ligase, leading to RBM39 polyubiquitination and proteasomal degradation.
Tasisulam (LY-573636) causes aberrant pre-mRNA splicing.
| M.Wt | 415.1 | |
| Formula | C11H6BrCl2NO3S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
N-[(5-bromo-2-thienyl)sulfonyl]-2,4-dichloro-benzamide |
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1. Meier T, et al. Mol Cancer Ther. 2011 Nov;10(11):2168-78.
2. Haritunians T, et al. Oncol Rep. 2008 Nov;20(5):1237-42.
3. Han T, et al. Science. 2017 Apr 28;356(6336). pii: eaal3755.
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