Catalog No.: PC-62312Not For Human Use, Lab Use Only.
Tasisulam (LY 573636) is a small molecule antitumor agent that induces apoptosis via the intrinsic pathway, resulting in cytochrome c release and caspase-dependent cell death.
Tasisulam sodium (LY-573636) is a small molecule antitumor agent that induces apoptosis via the intrinsic pathway, resulting in cytochrome c release and caspase-dependent cell death.
Tasisulam sodium shows antiproliferative effect against a variety of human hematopoietic malignancies, including AML, B-ALL, large B-cell and mantle cell lymphoma cell lines.
Tasisulam sodium promotes the recruitment of RBM39 to the CUL4-DCAF15 E3 ubiquitin ligase, leading to RBM39 polyubiquitination and proteasomal degradation.
Tasisulam sodium causes aberrant pre-mRNA splicing.
Physicochemical Properties
M.Wt
437.09
Formula
C11H5BrCl2NNaO3S2
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
N-[(5-bromo-2-thienyl)sulfonyl]-2,4-dichloro-benzamide sodium salt
References
1. Meier T, et al. Mol Cancer Ther. 2011 Nov;10(11):2168-78.
2. Haritunians T, et al. Oncol Rep. 2008 Nov;20(5):1237-42.
3. Han T, et al. Science. 2017 Apr 28;356(6336). pii: eaal3755.
