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Chemical Structure : Tasquinimod
CAS No.: 254964-60-8
Catalog No.: PC-42638Not For Human Use, Lab Use Only.
An orally active antiangiogenic agent with anti-prostate cancer activity, an allosteric modulator of HDAC4 with Kd of 10-30 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $138 | In stock | |
| 10 mg | $218 | In stock | |
| 25 mg | $368 | In stock | |
| 50 mg | $558 | In stock | |
| 100 mg | Get quote |
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Tasquinimod (ABR215050) is an orally active antiangiogenic agent with anti-prostate cancer activity, an allosteric modulator of HDAC4 with Kd of 10-30 nM.
Tasquinimod inhibits colocalization of N-CoR/HDAC3, thereby inhibiting deacetylation of histones and HDAC4 client transcription factors, such as HIF-1α.
Tasquinimod also is a S100A9 inhibitor.
| M.Wt | 406.3552 | |
| Formula | C20H17F3N2O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 42 mg/mL |
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| Chemical Name/SMILES |
3-Quinolinecarboxamide, 1,2-dihydro-4-hydroxy-5-methoxy-N,1-dimethyl-2-oxo-N-[4-(trifluoromethyl)phenyl]- |
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1. Isaacs JT, et al. Prostate. 2006 Dec 1;66(16):1768-78.
2. Olsson A, et al. Mol Cancer. 2010 May 17;9:107.
3. Dalrymple SL, et al. Prostate. 2012 May 1;72(6):638-48.
4. Isaacs JT, et al. Cancer Res. 2013 Feb 15;73(4):1386-99.
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