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Tauroursodeoxycholic acid sodium

Chemical Structure : Tauroursodeoxycholic acid sodium

CAS No.: 35807-85-3

Tauroursodeoxycholic acid sodium (TUDCA)

Catalog No.: PC-45672Not For Human Use, Lab Use Only.

Tauroursodeoxycholic acid (TUDCA) is a neuroprotective bile conjugate, prevents Bax translocation both in vitro and in vivo, thereby preserving mitochondrial function and suppressing apoptosis.

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Biological Activity

Tauroursodeoxycholic acid (TUDCA) is a neuroprotective bile conjugate, prevents Bax translocation both in vitro and in vivo, thereby preserving mitochondrial function and suppressing apoptosis.
TUDCA inhibits nuclear factor-kappa B (NF-κB) activation in glial cells.
TUDCA shows anti-inflammatory effect by inducing TGF-β pathway.
TUDCA also inhibits TNFα-induced lipolysis.

Physicochemical Properties

M.Wt 521.6854
Formula C26H44NNaO6S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

H2O: ≥ 39 mg/mL

Chemical Name/SMILES

Ethanesulfonic acid, 2-[[(3α,5β,7β)-3,7-dihydroxy-24-oxocholan-24-yl]amino]-, sodium salt (1:1)

References

1. Romero-Ramirez L, et al. Neural Regen Res. 2017 Jan;12(1):62-63.

2. Xia W, et al. Mol Med Rep. 2017 Apr;15(4):1753-1758.

3. Rani S, et al. PLoS One. 2017 Apr 20;12(4):e0176071.

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