Catalog No.: PC-45672Not For Human Use, Lab Use Only.
Tauroursodeoxycholic acid (TUDCA) is a neuroprotective bile conjugate, prevents Bax translocation both in vitro and in vivo, thereby preserving mitochondrial function and suppressing apoptosis.
Tauroursodeoxycholic acid (TUDCA) is a neuroprotective bile conjugate, prevents Bax translocation both in vitro and in vivo, thereby preserving mitochondrial function and suppressing apoptosis.
TUDCA inhibits nuclear factor-kappa B (NF-κB) activation in glial cells.
TUDCA shows anti-inflammatory effect by inducing TGF-β pathway.
TUDCA also inhibits TNFα-induced lipolysis.
Physicochemical Properties
M.Wt
521.6854
Formula
C26H44NNaO6S
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
H2O: ≥ 39 mg/mL
Chemical Name/SMILES
Ethanesulfonic acid, 2-[[(3α,5β,7β)-3,7-dihydroxy-24-oxocholan-24-yl]amino]-, sodium salt (1:1)
References
1. Romero-Ramirez L, et al. Neural Regen Res. 2017 Jan;12(1):62-63.
2. Xia W, et al. Mol Med Rep. 2017 Apr;15(4):1753-1758.
3. Rani S, et al. PLoS One. 2017 Apr 20;12(4):e0176071.
