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Tec Kinase-IN-21

Chemical Structure : Tec Kinase-IN-21

CAS No.: 931664-41-4

Tec Kinase-IN-21

Catalog No.: PC-60854Not For Human Use, Lab Use Only.

Tec Kinase-IN-21 is a selective small molecule toward Tec kinase-mediated tyrosine phosphorylation of FGF2 with IC50 of 11.7 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    Tec Kinase-IN-21 is a selective small molecule toward Tec kinase-mediated tyrosine phosphorylation of FGF2 with IC50 of 11.7 uM.
    Tec Kinase-IN-21 inhibits Tec-FGF2 complex and blocks tyrosine phosphorylation of FGF2 in cells, also inhibit FGF2 secretion from cells.

    Physicochemical Properties

    M.Wt 362.832
    Formula C16H15ClN4O2S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    1-(4-acetyl-3,5-dimethyl-1H-pyrrol-2-yl)-2-((6-chloro-3H-imidazo[4,5-b]pyridin-2-yl)thio)ethan-1-one

    References

    1. La Venuta G, et al. J Biol Chem. 2016 Aug 19;291(34):17787-803.

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