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Chemical Structure : Teclistamab
Catalog No.: PC-38852Not For Human Use, Lab Use Only.
Teclistamab (JNJ-64007957) is a BCMAxCD3 bispecific antibody, recruits and activates T cells to kill BCMA-expressing MM cells.
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Teclistamab (JNJ-64007957) is a BCMAxCD3 bispecific antibody, recruits and activates T cells to kill BCMA-expressing MM cells.
Teclistamab induced cytotoxicity of BCMA+ MM cell lines in vitro (H929 cells, EC50=0.15 nM; MM.1R cells, EC50=0.06 nM; RPMI 8226 cells, EC50=0.45 nM).
Teclistamab also depleted BCMA+ cells in bone marrow samples from MM patients in an ex vivo assay with an average EC50 value of 1.7 nM.
Teclistamab demonstrated excellent antitumor activity BCMA+ MM murine xenograft models inoculated with human T cells (tumor inhibition with H929 model and tumor regression with the RPMI 8226 model).
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| Appearance | Solid | |
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10 mM in DMSO |
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