Teclistamab | Anti-BCMA/CD3 | Probechem Biochemicals

Chemical Structure : Teclistamab

Teclistamab (JNJ-64007957)

Catalog No.: PC-38852Not For Human Use, Lab Use Only.

Teclistamab (JNJ-64007957) is a BCMAxCD3 bispecific antibody, recruits and activates T cells to kill BCMA-expressing MM cells.

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Biological Activity

Teclistamab (JNJ-64007957) is a BCMAxCD3 bispecific antibody, recruits and activates T cells to kill BCMA-expressing MM cells.
Teclistamab induced cytotoxicity of BCMA+ MM cell lines in vitro (H929 cells, EC50=0.15 nM; MM.1R cells, EC50=0.06 nM; RPMI 8226 cells, EC50=0.45 nM).
Teclistamab also depleted BCMA+ cells in bone marrow samples from MM patients in an ex vivo assay with an average EC50 value of 1.7 nM.
Teclistamab demonstrated excellent antitumor activity BCMA+ MM murine xenograft models inoculated with human T cells (tumor inhibition with H929 model and tumor regression with the RPMI 8226 model).

Physicochemical Properties

M.Wt
Formula
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES

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Teclistamab (JNJ-64007957)

Biological Activity

Physicochemical Properties

References

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