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Tegobuvir

Chemical Structure : Tegobuvir

CAS No.: 1000787-75-6

Tegobuvir (GS333126, GS9190, GS-333126, GS-9190)

Catalog No.: PC-42646Not For Human Use, Lab Use Only.

Tegobuvir (GS-333126, GS-9190) is a nonnucleoside inhibitor of HCV NS5B polymerase that acts as a potent inhibitor of HCV genotype 1.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Tegobuvir (GS-333126, GS-9190) is a nonnucleoside inhibitor of HCV NS5B polymerase that acts as a potent inhibitor of HCV genotype 1.
Tegobuvir inhibits 1a (H77) and 1b (Con-1) replicons with EC50 of 13.8 nM and 0.8 nM respectively, and displays a loss in potency against 2a (JFH-1) virus with EC50 of 2.9 uM.

Physicochemical Properties

M.Wt 517.401
Formula C25H14F7N5
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

5H-Imidazo[4,5-c]pyridine, 5-[[6-[2,4-bis(trifluoromethyl)phenyl]-3-pyridazinyl]methyl]-2-(2-fluorophenyl)-

References

1. Shih IH, et al. Antimicrob Agents Chemother. 2011 Sep;55(9):4196-203.

2. Zeuzem S, et al. Hepatology. 2012 Mar;55(3):749-58.

3. Wong KA, et al. Virology. 2012 Jul 20;429(1):57-62.

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