Catalog No.: PC-60811Not For Human Use, Lab Use Only.
Tegoprazan (CJ 12420, RQ-00000004, RQ-4) is a novel potent, highly selective, competitive and orally active inhibitor of gastric H+/K+-ATPase with IC50 of ranging 0.29-0.52 uM porcine, canine and human H+/K+-ATPases in vitro.
Tegoprazan (CJ 12420, RQ-00000004, RQ-4) is a novel potent, highly selective, competitive and orally active inhibitor of gastric H+/K+-ATPase with IC50 of ranging 0.29-0.52 uM porcine, canine and human H+/K+-ATPases in vitro.
Tegoprazan displays no activity against canine kidney Na+/K+-ATPase (IC50>100 uM).
Tegoprazan potently inhibits histamine-induced gastric acid secretion in dogs and a complete inhibition at 1.0 mg/kg starting from 1 hr after administration, reverses the pentagastrin-induced acidified gastric pH to the neutral range at 1-3 mg/kg, immediately evoks a gastric phase III contraction of migrating motor complex (MMC) in pentagastrin-treated dogs.
