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Chemical Structure : Tegoprazan
CAS No.: 942195-55-3
Catalog No.: PC-60811Not For Human Use, Lab Use Only.
Tegoprazan (CJ 12420, RQ-00000004, RQ-4) is a novel potent, highly selective, competitive and orally active inhibitor of gastric H+/K+-ATPase with IC50 of ranging 0.29-0.52 uM porcine, canine and human H+/K+-ATPases in vitro.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $118 | In stock | |
| 10 mg | $178 | In stock | |
| 25 mg | $298 | In stock | |
| 50 mg | $488 | In stock | |
| 100 mg | Get quote |
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Tegoprazan (CJ 12420, RQ-00000004, RQ-4) is a novel potent, highly selective, competitive and orally active inhibitor of gastric H+/K+-ATPase with IC50 of ranging 0.29-0.52 uM porcine, canine and human H+/K+-ATPases in vitro.
Tegoprazan displays no activity against canine kidney Na+/K+-ATPase (IC50>100 uM).
Tegoprazan potently inhibits histamine-induced gastric acid secretion in dogs and a complete inhibition at 1.0 mg/kg starting from 1 hr after administration, reverses the pentagastrin-induced acidified gastric pH to the neutral range at 1-3 mg/kg, immediately evoks a gastric phase III contraction of migrating motor complex (MMC) in pentagastrin-treated dogs.
| M.Wt | 387.387 | |
| Formula | C20H19F2N3O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(S)-4-((5,7-difluorochroman-4-yl)oxy)-N,N,2-trimethyl-1H-benzo[d]imidazole-6-carboxamide |
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1. Takahashi N, et al. J Pharmacol Exp Ther. 2017 Nov 27. pii: jpet.117.244202.
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