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Telaprevir

Chemical Structure : Telaprevir

CAS No.: 402957-28-2

Telaprevir (VX-950, VX950)

Catalog No.: PC-42476Not For Human Use, Lab Use Only.

Telaprevir (VX-950) is a potent, selective, covalent, orally bioavailable inhibitor of HCV NS3/4A protease with Ki of 7 nM.

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Biological Activity

Telaprevir (VX-950) is a potent, selective, covalent, orally bioavailable inhibitor of HCV NS3/4A protease with Ki of 7 nM.
Telaprevir demonstrates excellent antiviral activity both in genotype 1b HCV replicon cells (IC50=354 nM) and in human fetal hepatocytes (IC50=280 nM).
Telaprevir shows excellent viral inhibition in vivo with favorable pharmacokinetic profile.

Physicochemical Properties

M.Wt 679.8493
Formula C36H53N7O6
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

Cyclopenta[c]pyrrole-1-carboxamide, (2S)-2-cyclohexyl-N-(2-pyrazinylcarbonyl)glycyl-3-methyl-L-valyl-N-[(1S)-1-[2-(cyclopropylamino)-2-oxoacetyl]butyl]octahydro-, (1S,3aR,6aS)-

References

1. Perni RB, et al. Antimicrob Agents Chemother. 2006 Mar;50(3):899-909.

2. Lin C, et al. J Biol Chem. 2004 Apr 23;279(17):17508-14.

3. Lin C, et al. J Biol Chem. 2005 Nov 4;280(44):36784-91.

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