Catalog No.: PC-43355Not For Human Use, Lab Use Only.
Telotristat etiprate (LX1606 hippurate) is an orally active, small-molecule inhibitor of peripheral serotonin synthesis, acts by inhibiting tryptophan hydroxylase (TPH) with IC50 of 28 nM, demonstrates potential for the treatment of carcinoid syndrome.
Telotristat etiprate (LX1606 hippurate) is an orally active, small-molecule inhibitor of peripheral serotonin synthesis, acts by inhibiting tryptophan hydroxylase (TPH) with IC50 of 28 nM, demonstrates potential for the treatment of carcinoid syndrome.
Physicochemical Properties
M.Wt
754.1546
Formula
C36H35ClF3N7O6
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
DMSO: ≥ 28 mg/mL
Chemical Name/SMILES
L-Phenylalanine, 4-[2-amino-6-[(1R)-1-[4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl]-2,2,2-trifluoroethoxy]-4-pyrimidinyl]-, ethyl ester, compd. with N-benzoylglycine (1:1)
References
1. Margolis KG, et al. Gut. 2014 Jun;63(6):928-37.
2. Kulke MH, et al. Endocr Relat Cancer. 2014 Oct;21(5):705-14.
3. Kulke MH, et al. J Clin Oncol. 2017 Jan;35(1):14-23.
4. Kim JJ, et al. Am J Physiol Gastrointest Liver Physiol.
