Temsavir (BMS-626529)

Chemical Structure : Temsavir

CAS No.: 701213-36-7

Catalog No.: PC-38563Not For Human Use, Lab Use Only.

Temsavir (BMS-626529) is a highly potent, small molecule HIV-1 attachment inhibitor with IC50 values of 2.26 nM, 0.34 nM and 1.3 nM for HIV-1 subtype A, B, and C envelope, repectively.

Packing	Price	Stock
5 mg	$98	In stock
10 mg	$148	In stock
25 mg	$258	In stock
50 mg	$398	In stock
100 mg	$588	In stock
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Biological Activity

Temsavir (BMS-626529) is a highly potent, small molecule HIV-1 attachment inhibitor with IC50 values of 2.26 nM, 0.34 nM and 1.3 nM for HIV-1 subtype A, B, and C envelope, repectively.
Temsavir (BMS-626529) binds to non-ligand bound HIV-1 gp120 to inhibit HIV-1 interaction with host CD4+ T cells and subsequent HIV-1 binding and cell entry.
Temsavir (BMS-626529) inhibits infectivity of laboratory strains and clinical isolates of HIV-1 with EC50s of 0.4-2,000 nM, with no significant cytotoxic effect.
Temsavir (BMS-626529) is the active form of Fostemsavir.

Physicochemical Properties

M.Wt	473.5
Formula	C24H23N7O4
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(4-benzoylpiperazin-1-yl)-2-[4-methoxy-7-(3-methyl-1,2,4-triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]ethane-1,2-dione

References

1. Meanwell NA, et al. J Med Chem. 2018 Jan 11;61(1):62-80.

2. Wang T, et al. J Med Chem. 2018 Jul 26;61(14):6308-6327.

3. Lai YT, et al. Nat Commun. 2019 Jan 3;10(1):47.