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Chemical Structure : Tenapanor
CAS No.: 1234423-95-0
Catalog No.: PC-63147Not For Human Use, Lab Use Only.
Tenapanor (AZD-1722, RDX5791) is a potent, selective inhibitor of the Na+/H+ exchanger 3 (NHE3) with IC50 of 5 and 10 nM for human and rat NHE3, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $88 | In stock | |
| 10 mg | $128 | In stock | |
| 25 mg | $218 | In stock | |
| 50 mg | $358 | In stock | |
| 100 mg | Get quote |
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Tenapanor (AZD-1722, RDX5791) is a potent, selective inhibitor of the Na+/H+ exchanger 3 (NHE3) with IC50 of 5 and 10 nM for human and rat NHE3, respectively.
Tenapanor (AZD-1722, RDX5791) displays no inhibitory activities against human intestinal transporters NHE1 (SLC9A1), NHE2 (SLC9A2), TGR5 (GPBAR1), ASBT and Pit-1.
Tenapanor (AZD-1722, RDX5791) inhibits sodium uptake acted exclusively in the gastrointestinal tract in vivo, reduces extracellular fluid volume, left ventricular hypertrophy, albuminuria, and blood pressure in salt-fed nephrectomized rats.
Tenapanor (AZD-1722, RDX5791) also reduces sodium and phosphorus absorption, protects against vascular calcification in rat model of CKD.
| M.Wt | 1145.044 | |
| Formula | C50H66Cl4N8O10S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
3-((S)-6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)-N-(26-((3-((S)-6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)phenyl)sulfonamido)-10,17-dioxo-3,6,21,24-tetraoxa-9,11,16,18-tetraazahexacosyl)benzenesulfonamide |
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1. Spencer AG, et al. Sci Transl Med. 2014 Mar 12;6(227):227ra36.
2. Labonté ED, et al. J Am Soc Nephrol. 2015 May;26(5):1138-49.
3. Zielińska M, et al. Expert Opin Investig Drugs. 2015;24(8):1093-9.
4. Block GA, et al. Clin J Am Soc Nephrol. 2016 Sep 7;11(9):1597-605.
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