Tetrazole compound D2

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Chemical Structure : Tetrazole compound D2

Catalog No.: PC-22136Not For Human Use, Lab Use Only.

Tetrazole compound D2 is a novel antifungal inhibitor with MIC values of <0.008, <0.008, and 2 μg/mL against Candida albicans, Cryptococcus neoformans, and Aspergillus fumigatus, respectively.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Tetrazole compound D2 is a novel antifungal inhibitor with MIC values of <0.008, <0.008, and 2 μg/mL against Candida albicans, Cryptococcus neoformans, and Aspergillus fumigatus, respectively.
Tetrazole compound D2 also exhibits potent activity against fluconazole-resistant C. auris isolates with MIC value of <0.125-1 ug/mL. Tetrazole compound D2 showed better in vivo efficacy than albaconazole at reducing fungal burden and extending the survival of C. albicans-infected mice.

Physicochemical Properties

M.Wt	431.83
Formula	C20H16ClF2N5O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	6-chloro-2-((2R,3R)-3-(2,4-difluorophenyl)-3-hydroxy-4-(1H-tetrazol-1-yl)butan-2-yl)isoquinolin-1(2H)-one

References

1. Ni T, et al. J Med Chem. 2024 Apr 10. doi: 10.1021/acs.jmedchem.3c02188.

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