Tetrodotoxin citrate | Nav1.6 inhibitor

Chemical Structure : Tetrodotoxin citrate

Tetrodotoxin citrate (TTx citrate)

Catalog No.: PC-43095Not For Human Use, Lab Use Only.

Tetrodotoxin (TTx) is a potent, highly selective sodium channel blocker with IC50 of 33 nM for Nav1.6.

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Biological Activity

Tetrodotoxin (TTx) is a potent, highly selective sodium channel blocker with IC50 of 33 nM for Nav1.6.
Tetrodotoxin-sensitive sodium channel (Nav) family includes Nav1.1, Nav1.2, Nav1.3, Nav1.4, Nav1.6, and Nav1.7, the Nav1.5, Nav1.8, and Nav1.9 channels are TTX-resistant.
Tetrodotoxin inhibits the firing of action potentials in neurons by binding to the voltage-gated sodium channels in nerve cell membranes and blocking the passage of sodium ions into the neuron.

Physicochemical Properties

M.Wt	511.3915
Formula	C17H25N3O15
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	H2O
Chemical Name/SMILES	5,9:7,10a-Dimethano-10aH-[1,3]dioxocino[6,5-d]pyrimidine-4,7,10,11,12-pentol, 2-amino-1,4,4a,5,9,10-hexahydro-12-(hydroxymethyl)-, 2-hydroxy-1,2,3-propanetricarboxylate (1:1), [C(S),C(S),C(S),3S,4S,5R,9R,10R,11R]-

References

1. Rogers M, et al. Assay Drug Dev Technol. 2016 Mar;14(2):109-30.

2. Frelin C, et al. J Biol Chem. 1983 Jun 25;258(12):7256-9.

3. Reiser G, et al. Brain Res. 1983 Feb 21;261(2):335-40.

Tetrodotoxin citrate (TTx citrate)

Biological Activity

Physicochemical Properties

References

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