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Tezampanel

Chemical Structure : Tezampanel

CAS No.: 150131-78-5

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Tezampanel (LY 293558;NGX 424)

Catalog No.: PC-61713Not For Human Use, Lab Use Only.

Tezampanel (LY 293558, NGX 424) is a competitive antagonist of the AMPA and kainate receptors with selectivity for the GluR5 subtype of the kainate receptor.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    Tezampanel (LY 293558, NGX 424) is a competitive antagonist of the AMPA and kainate receptors with selectivity for the GluR5 subtype of the kainate receptor.
    Tezampanel (LY 293558, NGX 424) has neuroprotective and anticonvulsant properties, also has anxiolytic effects in animal studies.

    Physicochemical Properties

    M.Wt 279.344
    Formula C13H21N5O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (3S,4aR,6R,8aR)-6-[2-(1H-tetrazol-5-yl)ethyl]decahydroisoquinoline-3-carboxylic acid

    References

    1. Ornstein PL, et al. J Med Chem. 1993 Jul 9;36(14):2046-8.

    2. LeBlanc MH, et al. Stroke. 1995 Oct;26(10):1908-14; discussion 1914-5.

    3. Benvenga MJ, et al. J Pharmacol Exp Ther. 1995 Oct;275(1):164-70.

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