Thapsigargin (G202) | SERCA inhibitor | Probechem Biochemicals

Chemical Structure : Thapsigargin

CAS No.: 67526-95-8

Thapsigargin (G-202, G202)

Catalog No.: PC-60883Not For Human Use, Lab Use Only.

Thapsigargin (G202) is a potent, selective, non-competitive inhibitor of the sarco/endoplasmic reticulum Ca2+ ATPase (SERCA), causes ER stress and induces autophagy in mammalian cells.

Packing	Price	Stock
5 mg	$228	In stock
10 mg	$368	In stock
25 mg	$568	In stock
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Biological Activity

Thapsigargin (G202) is a potent, selective, non-competitive inhibitor of the sarco/endoplasmic reticulum Ca2+ ATPase (SERCA), causes ER stress and induces autophagy in mammalian cells.
Thapsigargin inhibits the Ca2+ ATPase of rat liver ER about 100% at 170 nM, but no inhibition for skeletal muscle SR.
Thapsigargin increases the concentration of cytosolic free Ca2+ in sensitive cells by an acute and highly specific arrest of the endoplasmic reticulum Ca2+ pump.
Thapsigargin also efficiently inhibits coronavirus (HCoV-229E, MERS-CoV, SARS-CoV-2) replication.

Physicochemical Properties

M.Wt	650.76
Formula	C34H50O12
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(3S,3aR,4S,6S,6AR,7S,8S,9bS)-6- (Acetyloxy)-2,3,3a,4,5,6,6a,7,8,9b-decahydro-3,3a-dihydroxy-3,6,9-trimethyl-8-[[(2Z)-2-methyl-1-oxo-2-butenyl]oxy]-2-oxo-4-(1-oxobutoxy)azuleno[4,5-b]furan-7-yl octanoate

References

1. Davidson GA, et al. J Biol Chem. 1995 May 19;270(20):11731-4.

2. Thastrup O, et al. Proc Natl Acad Sci U S A. 1990 Apr;87(7):2466-70.

3. Yu M, et al. J Biol Chem. 1998 Feb 6;273(6):3542-6.

4. Panagaki T, et al. Sci Rep. 2017 Nov 23;7(1):16158.

Thapsigargin (G-202, G202)

Biological Activity

Physicochemical Properties

References

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