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Thiazovivin

Chemical Structure : Thiazovivin

CAS No.: 1226056-71-8

Thiazovivin

Catalog No.: PC-43437Not For Human Use, Lab Use Only.

Thiazovivin is a small molecule inhibitor of ROCK, dramatically improves (200-fold) the efficiency of iPSC generation from human fibroblasts.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Thiazovivin is a small molecule inhibitor of ROCK, dramatically improves (200-fold) the efficiency of iPSC generation from human fibroblasts.
Thiazovivin dramatically improves the survival of hESCs upon trypsinization.
Addition of Thiazovivin to cocktail of SB431542 and PD0325901 also vastly improves the survival of iPSCs after splitting by trypsinization.
Thiazovivin induces porcine embryonic fibroblasts into adipocytes.

Physicochemical Properties

M.Wt 311.36
Formula C15H13N5OS
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 30 mg/mL

Chemical Name/SMILES

4-Thiazolecarboxamide, N-(phenylmethyl)-2-(4-pyrimidinylamino)-

References

1. Lin T, et al. Nat Methods. 2009 Nov;6(11):805-8.

2. Zhu J, et al. Cell Reprogram. 2012 Apr;14(2):99-105.

3. Wang F, et al. Gastroenterology. 2013 Aug;145(2):383-95.e1-21.

4. Mohseni R, et al. Cell Biol Int. 2015 May;39(5):515-8.

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