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Thymoquinone

Chemical Structure : Thymoquinone

CAS No.: 490-91-5

Thymoquinone

Catalog No.: PC-70009Not For Human Use, Lab Use Only.

Thymoquinone is an anticancer phytochemical commonly found in black cumin, exhibits anticancer activity via numerous mechanisms of action, specifically by showing selective antioxidant and oxidant activity.

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Biological Activity

Thymoquinone is an anticancer phytochemical commonly found in black cumin, exhibits anticancer activity via numerous mechanisms of action, specifically by showing selective antioxidant and oxidant activity.
Thymoquinone directly suppresses IRAK1, strongly inhibits the production of nitric oxide (NO) and repressed NO synthase (iNOS),TNF-α, COX-2, IL-6, and IL-1β expression in LPS-activated RAW264.7 cells.
Thymoquinone significantly ameliorates disease symptoms in LPS/D-GalN-induced hepatitis and EtOH/HCl-induced gastritis mouse models.

Physicochemical Properties

M.Wt 164.2
Formula C10H12O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

2-isopropyl-5-methylcyclohexa-2,5-diene-1,4-dione

References

1. Khan MA, et al. Oncotarget. 2017 Apr 18. doi: 10.18632/oncotarget.17206.

2. Hossen MJ, et al. Sci Rep. 2017 Feb 20;7:42995.

3. Rukoyatkina N, et al. Cell Death Dis. 2017 Jun 29;8(6):e2898.

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