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Thyroid hormone receptor antagonist 1-850

Chemical Structure : Thyroid hormone receptor antagonist 1-850

CAS No.: 251310-57-3

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Thyroid hormone receptor antagonist 1-850 (TR-antagonist 1-850)

Catalog No.: PC-28093Not For Human Use, Lab Use Only.

Thyroid hormone receptor antagonist 1-850 (1-850) is a specific small molecule antagonst of thyroid hormone receptor (TR), antagonizes the effect of T3 on TR with IC50 of 1.5 uM, effectively blocks thyroid hormone-dependent gene expression.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Thyroid hormone receptor antagonist 1-850 (1-850) is a specific small molecule antagonst of thyroid hormone receptor (TR, THR), antagonizes the effect of T3 on TR with IC50 of 1.5 uM, effectively blocks thyroid hormone-dependent gene expression.

Physicochemical Properties

M.Wt 463.42
Formula C21H20F3N5O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-(2-(1-(4-nitrophenyl)piperidin-4-ylidene)acetyl)-N-(3-(trifluoromethyl)phenyl)hydrazine-1-carboxamide

References

1. Schapira M, et al. Proc Natl Acad Sci U S A. 2003 Jun 10;100(12):7354-9.

2. Westerholz S, et al. Neuroscience. 2010 Jun 30;168(2):573-89.

3. Navarrete-Ramírez P, et al. J Mol Endocrinol. 2014 Feb 1;52(1):1-9.

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