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TiY

Chemical Structure : TiY

CAS No.:

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TiY (TIC Fluorescent Probe TiY)

Catalog No.: PC-62598Not For Human Use, Lab Use Only.

TiY (TIC Fluorescent Probe TiY) is the first TIC (tumor initiating cell)-specific fluorescent chemical probe, target vimentin, a marker for epithelial-to-mesenchymal transition (EMT).

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

TiY (TIC Fluorescent Probe TiY) is the first TIC (tumor initiating cell)-specific fluorescent chemical probe, target vimentin, a marker for epithelial-to-mesenchymal transition (EMT); selectively stains TICs over differentiated tumor cells or normal cells, and facilitates the visualization and enrichment of functionally active TICs from patient tumors; also shows anti-TIC activity with low toxicity to non-TICs at high concentration.

Physicochemical Properties

M.Wt 541.875
Formula C29H35BClF2N3O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(E)-N-(2-(3-(3-(tert-butyl)-2-propoxystyryl)-5,5-difluoro-1-methyl-5H-5l4,6l4-dipyrrolo[1,2-c:2',1'-f][1,3,2]diazaborinin-10-yl)ethyl)-2-chloroacetamide

References

1. Lee YA, et al. Angew Chem Int Ed Engl. 2018 Jan 26.

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