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Tiagabine hydrochloride

Chemical Structure : Tiagabine hydrochloride

CAS No.: 145821-59-6

Tiagabine hydrochloride (NO050328, NO328)

Catalog No.: PC-24080Not For Human Use, Lab Use Only.

Tiagabine hydrochloride is an anticonvulsant agent and selective inhibitor of
GABA transporter 1 (GAT1) with Ki of 0.1 uM, potently and selectively inhibits GABA reuptake with IC50 of 67, 446 and 182 nM for [3H]GABA uptake in synaptosomes, neurons and glia, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Tiagabine hydrochloride is an anticonvulsant agent and selective inhibitor of
GABA transporter 1 (GAT1) with Ki of 0.1 uM, potently and selectively inhibits GABA reuptake with IC50 of 67, 446 and 182 nM for [3H]GABA uptake in synaptosomes, neurons and glia, respectively.

Physicochemical Properties

M.Wt 412.00
Formula C20H26ClNO2S2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(R)-1-(4,4-Bis(3-methylthiophen-2-yl)but-3-en-1-yl)piperidine-3-carboxylic acid hydrochloride

References

1. Braestrup C, et al. J Neurochem. 1990 Feb;54(2):639-47.

2. Henjum S, Neurochem Int. 2007 Jan;50(2):365-70.

3. Sheehan DV, et al. Psychopharmacol Bull. 2007;40(3):32-40.

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