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Chemical Structure : Tianeptinaline
Catalog No.: PC-35280Not For Human Use, Lab Use Only.
Tianeptinaline is a class I HDAC-selective, brain penetrant analogue of tianeptine with IC50 of 0.24, 0.12 and 0.155 uM for HDAC1, 2 and 3 respectively, does not inhibit HDAC6.
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Tianeptinaline is a class I HDAC-selective, brain penetrant analogue of tianeptine with IC50 of 0.24, 0.12 and 0.155 uM for HDAC1, 2 and 3 respectively, does not inhibit HDAC6.
Tianeptinaline has EC50 of 3.98 and 0.67 uM in H3K9ac and H4K12ac assays, respectively。
Tianeptinaline increases histone acetylation, and enhances CREB-mediated transcription and the expression of Arc (activity-regulated cytoskeleton-associated protein)。
Tianeptinaline enhances contextual fear conditioning, a behavioral test of hippocampal-dependent memory, after in vivo administration.
| M.Wt | 527.08 | |
| Formula | C27H31ClN4O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Zhao WN, et al. ACS Chem Neurosci. 2018 Jun 22. doi: 10.1021/acschemneuro.8b00116.
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