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Tilmacoxib

Chemical Structure : Tilmacoxib

CAS No.: 180200-68-4

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Tilmacoxib (JTE-522, RWJ57504)

Catalog No.: PC-62672Not For Human Use, Lab Use Only.

Tilmacoxib (JTE-522) is a potent, selective inhibitor of cyclooxygenase-2 (COX-2) that inhibits human recombinant COX-2 with IC50 of 85 nM, dispalys no activity against COX-1 (IC50>100 uM).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    Tilmacoxib (JTE-522) is a potent, selective inhibitor of cyclooxygenase-2 (COX-2) that inhibits human recombinant COX-2 with IC50 of 85 nM, dispalys no activity against COX-1 (IC50>100 uM).
    Tilmacoxib significantly inhibits fibrosis, also inhibits growth of pulmonary metastases of colorectal cancer in rats.

    Physicochemical Properties

    M.Wt 338.397
    Formula C16H19FN2O3S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    4-(4-cyclohexyl-2-methyl-1,3-oxazol-5-yl)-2-fluorobenzenesulfonamide

    References

    1. Wakitani K, et al. Jpn J Pharmacol. 1998 Nov;78(3):365-71.

    2. Kobayashi H, et al. BMC Cancer. 2005 Mar 3;5:26.

    3. Yamamoto H, et al. Gastroenterology. 2003 Aug;125(2):556-71.

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