Chemical Structure : Tipifarnib S enantiomer
CAS No.:
192185-71-0
Tipifarnib S enantiomer
((S)-(-)-R-115777;IND-58359 S enantiomer)
Catalog No. : PC-42625Not For Human Use, Lab Use Only.
Tipifarnib S enantiomer is a potent and selective inhibitor of FTase (farnesyltransferase).
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Purity & Documentation Purity:
>98% (HPLC) Select Batch: PC-4262501
Biological Activity
Tipifarnib S enantiomer is a potent and selective inhibitor of FTase (farnesyltransferase) ; inhibits the farnesylation of lamin B and K-RasB peptide substrates with IC50s of 0.86 nM and 7.9 nM, respectively; no activity for PGGT1(IC50>50 uM); shows sensiticity for tumor cell lines bearing H-ras or N-ras mutations; inhibits the growth of tumors bearing mice and orally bioavailable.
Blood Cancer
Phase 3 Clinical
Physicochemical Properties
M.Wt
489.3958
Formula
C27H22Cl2N4O
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
2(1H)-Quinolinone, 6-[(S)-amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl]-4-(3-chlorophenyl)-1-methyl-
References
1. End DW, et al. Cancer Res. 2001 Jan 1;61(1):131-7.
2. Kelland LR, et al. Clin Cancer Res. 2001 Nov;7(11):3544-50.
3. Beaupre DM, et al. Mol Cancer Ther. 2004 Feb;3(2):179-86.
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