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Chemical Structure : Tipiracil hydrochloride
CAS No.: 183204-72-0
Catalog No.: PC-35966Not For Human Use, Lab Use Only.
Tipiracil hydrochloride (TPase inhibitor TPI) is a potent, selective inhibitor of thymidine phosphorylase (TPase) with Ki of 17 nM, does not inhibit uridine phosphorylase, thymidine kinase, orotate phosphoribosyltransferase, or dihydropyrimidine dehydrogenase.
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|---|---|---|---|
| 5 mg (Free Sample) | $28 | In stock | |
| 25 mg | $128 | In stock | |
| 50 mg | $198 | In stock | |
| 100 mg | $328 | In stock | |
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Tipiracil hydrochloride (TPase inhibitor TPI) is a potent, selective inhibitor of thymidine phosphorylase (TPase) with Ki of 17 nM, does not inhibit uridine phosphorylase, thymidine kinase, orotate phosphoribosyltransferase, or dihydropyrimidine dehydrogenase.
Oral administration of TPI significantly potentiated the antitumor activity of F(3)dThd on AZ-521 human stomach cancer xenografts in nude mice.
| M.Wt | 279.121 | |
| Formula | C9H12Cl2N4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
5-chloro-6-((2-iminopyrrolidin-1-yl)methyl)pyrimidine-2,4(1H,3H)-dione hydrochloride |
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1. Fukushima M, et al. Biochem Pharmacol. 2000 May 15;59(10):1227-36.
2. Sperotto N, et al. J Med Chem. 2019 Jan 7. doi: 10.1021/acs.jmedchem.8b01305.
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