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Chemical Structure : Tiplaxtinin
CAS No.: 393105-53-8
Catalog No.: PC-49768Not For Human Use, Lab Use Only.
Tiplaxtinin (PAI-039) is a selective, orally active plasminogen activator inhibitor-1 (PAI-1) inhibitor with IC50 of 2.7 uM and Kd of 0.48 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $188 | In stock | |
| 50 mg | $328 | In stock | |
| 100 mg | $498 | In stock | |
| 1 g | Get quote |
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Tiplaxtinin (PAI-039) is a selective, orally active plasminogen activator inhibitor-1 (PAI-1) inhibitor with IC50 of 2.7 uM and Kd of 0.48 uM.
Tiplaxtinin (PAI-039) exhibited in vivo oral efficacy in models of acute arterial thrombosis.
Tiplaxtinin (PAI-039) inhibited PAI-1 and accelerated fibrinolysis while maintaining normal coagulation in a model of coronary occlusion.
Tiplaxtinin (PAI-039) significantly attenuated Ang II-induced aortic medial and wall thickening, enhanced Ang II/salt-induced cardiac fibrosis.
Tiplaxtinin (PAI-039) effectively protected from L-NAME-induced thrombosis in murine model of hepatic vein thrombosis.
| M.Wt | 439.39 | |
| Formula | C24H16F3NO4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
{1-benzyl-5-[4-(trifluoromethoxy)phenyl]-1H-indol-3-yl}(oxo)acetic acid |
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1. Weisberg AD, et al. Arterioscler Thromb Vasc Biol. 2005 Feb;25(2):365-71.
2. Elokdah H, et al. J Med Chem. 2004 Jul 1;47(14):3491-4.
3. Hennan JK, et al. J Pharmacol Exp Ther. 2005 Aug;314(2):710-6.
4. Smith LH, et al. Blood. 2006 Jan 1;107(1):132-4.
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