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Tirofiban

Chemical Structure : Tirofiban

CAS No.: 144494-65-5

Tirofiban (L700462, MK-383, MK-0383)

Catalog No.: PC-45190Not For Human Use, Lab Use Only.

Tirofiban (L700462, MK-383, MK-0383) is a potent, selective inhibitor of the platelet fibrinogen receptor GPIIb/IIIa with IC50 of 9 nM, inhibition of platelet aggregation.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Tirofiban (L700462, MK-383, MK-0383) is a potent, selective inhibitor of the platelet fibrinogen receptor GPIIb/IIIa with IC50 of 9 nM, inhibition of platelet aggregation.
Tirofiban displays > 24,000-fold over human umbilical vein endothelial cell fibrinogen receptors.
Tirofiban inhibits ex vivo platelet aggregation induced by ADP in anesthetized dogs.

Physicochemical Properties

M.Wt 440.5966
Formula C22H36N2O5S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: < 1 mg/mL

Chemical Name/SMILES

L-Tyrosine, N-(butylsulfonyl)-O-[4-(4-piperidinyl)butyl]-

References

1. Hartman GD, et al. J Med Chem. 1992 Nov 27;35(24):4640-2.

2. Lynch JJ Jr, et al. J Pharmacol Exp Ther. 1995 Jan;272(1):20-32.

3. Cook NS, et al. Thromb Haemost. 1993 Nov 15;70(5):838-47.

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