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Tirofiban hydrochloride monohydrate

Chemical Structure : Tirofiban hydrochloride monohydrate

CAS No.: 150915-40-5

Tirofiban hydrochloride monohydrate (L-700462;MK-383;MK-0383)

Catalog No.: PC-45189Not For Human Use, Lab Use Only.

A potent, selective inhibitor of the platelet fibrinogen receptor GPIIb/IIIa with IC50 of 9 nM, inhibition of platelet aggregation.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

A potent, selective inhibitor of the platelet fibrinogen receptor GPIIb/IIIa with IC50 of 9 nM, inhibition of platelet aggregation; displays > 24,000-fold over human umbilical vein endothelial cell fibrinogen receptors; inhibits ex vivo platelet aggregation induced by ADP in anesthetized dogs.

Thrombosis

Approved

Physicochemical Properties

M.Wt 495.0728
Formula C22H39ClN2O6S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: 12 mg/mL

Chemical Name/SMILES

L-Tyrosine, N-(butylsulfonyl)-O-[4-(4-piperidinyl)butyl]-, hydrochloride, hydrate (1:1:1)

References

1. Hartman GD, et al. J Med Chem. 1992 Nov 27;35(24):4640-2.

2. Lynch JJ Jr, et al. J Pharmacol Exp Ther. 1995 Jan;272(1):20-32.

3. Cook NS, et al. Thromb Haemost. 1993 Nov 15;70(5):838-47.

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