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Tirofiban hydrochloride monohydrate

Chemical Structure : Tirofiban hydrochloride monohydrate

CAS No.: 150915-40-5

Tirofiban hydrochloride monohydrate (L700462, MK-383, MK-0383)

Catalog No.: PC-45189Not For Human Use, Lab Use Only.

Tirofiban hydrochloride monohydrate (L700462, MK-383, MK-0383) is a potent, selective inhibitor of the platelet fibrinogen receptor GPIIb/IIIa with IC50 of 9 nM, inhibition of platelet aggregation.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Tirofiban hydrochloride monohydrate (L700462, MK-383, MK-0383) is a potent, selective inhibitor of the platelet fibrinogen receptor GPIIb/IIIa with IC50 of 9 nM, inhibition of platelet aggregation.
Tirofiban displays > 24,000-fold over human umbilical vein endothelial cell fibrinogen receptors.
Tirofiban inhibits ex vivo platelet aggregation induced by ADP in anesthetized dogs.

Physicochemical Properties

M.Wt 495.0728
Formula C22H39ClN2O6S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: 12 mg/mL

Chemical Name/SMILES

L-Tyrosine, N-(butylsulfonyl)-O-[4-(4-piperidinyl)butyl]-, hydrochloride, hydrate (1:1:1)

References

1. Hartman GD, et al. J Med Chem. 1992 Nov 27;35(24):4640-2.

2. Lynch JJ Jr, et al. J Pharmacol Exp Ther. 1995 Jan;272(1):20-32.

3. Cook NS, et al. Thromb Haemost. 1993 Nov 15;70(5):838-47.

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