Catalog No.: PC-43149Not For Human Use, Lab Use Only.
Tizoxanide is the main metabolite of nitazoxanide, which is a synthetic nitrothiazolyl-salicylamide derivative and an antiprotozoal agent against anaerobic bacteria, protozoa, and a range of viruses.
Tizoxanide is the main metabolite of nitazoxanide, which is a synthetic nitrothiazolyl-salicylamide derivative and an antiprotozoal agent against anaerobic bacteria, protozoa, and a range of viruses.
Tizoxanide shows anti-HIV-1 activities and potent inhibition of both HBV and HCV replication with values EC50 of 0.46μM and 0.15 μM, respectively.
Tizoxanide also exerts anti-inflammatory effects by inhibiting the production of pro-inflammatory cytokines and suppressing of the activation of the NF-κB and the MAPK signaling pathways in LPS-treated macrophage cells.
Physicochemical Properties
M.Wt
265.2453
Formula
C10H7N3O4S
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
DMSO: ≥ 38 mg/mL
Chemical Name/SMILES
Benzamide, 2-hydroxy-N-(5-nitro-2-thiazolyl)-
References
1. Dubreuil L, et al. Antimicrob Agents Chemother. 1996 Oct;40(10):2266-70.
2. Gargala G, et al. J Antimicrob Chemother. 2000 Jul;46(1):57-60.
3. Adagu IS, et al. J Antimicrob Chemother. 2002 Jan;49(1):103-11.
4. Pankuch GA, et al. Antimicrob Agents Chemother. 2006 Mar;50(3):1112-7.
