Catalog No.: PC-38550Not For Human Use, Lab Use Only.
Todalam is a novel small molecule tubulin inhibitor with IC50 of 8.8 uM against HeLa cells, fully inhibits microtubule formation with IC50 of 48 uM, acting as a reversible microtubule-destabilizing agent in vitro and in cells.
Todalam is a novel small molecule tubulin inhibitor with IC50 of 8.8 uM against HeLa cells, fully inhibits microtubule formation with IC50 of 48 uM, acting as a reversible microtubule-destabilizing agent in vitro and in cells.
Todalam kills different type of mammalian cells, induces G2/M arrest, disrupts cellular microtubule networks, and can inhibit cell growth in a synergistic manner in combination with vinblastine.
Todalam achieves its effect by locking α-tubulin in an inactive conformational state and by sequestering tubulin dimers.
Todalam is the first-ever, fully rationally designed tubulin inhibitor with an original molecular mechanism of action.
