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Chemical Structure : Tolcapone
CAS No.: 134308-13-7
Catalog No.: PC-45228Not For Human Use, Lab Use Only.
Tolcapone (Ro 40-7592) selective, potent and reversible nitrocatechol-type inhibitor of catechol-O-methyltransferase (COMT) with IC50 of 700 nM.
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Tolcapone (Ro 40-7592) selective, potent and reversible nitrocatechol-type inhibitor of catechol-O-methyltransferase (COMT) with IC50 of 700 nM.
Tolcapone (Ro 40-7592) kills neuroblastoma (NB) cells in preclinical models by inhibition of COMT.
Tolcapone (Ro 40-7592) induces oxidative stress leading to apoptosis and inhibition of tumor growth in Neuroblastoma.
Tolcapone (Ro 40-7592) also is a potent Transthyretin (TTR) aggregation inhibitor.
| M.Wt | 273.2408 | |
| Formula | C14H11NO5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Methanone, (3,4-dihydroxy-5-nitrophenyl)(4-methylphenyl)- |
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1. Maj J, et al. J Neural Transm Park Dis Dement Sect. 1990;2(2):101-12.
2. Maser T, et al. Cancer Med. 2017 Jun;6(6):1341-1352.
3. Sant'Anna R, et al. Nat Commun. 2016 Feb 23;7:10787.
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