Tolcapone (Ro 40-7592) selective, potent and reversible nitrocatechol-type inhibitor of catechol-O-methyltransferase (COMT) with IC50 of 700 nM.
Tolcapone (Ro 40-7592) kills neuroblastoma (NB) cells in preclinical models by inhibition of COMT.
Tolcapone (Ro 40-7592) induces oxidative stress leading to apoptosis and inhibition of tumor growth in Neuroblastoma.
Tolcapone (Ro 40-7592) also is a potent Transthyretin (TTR) aggregation inhibitor.
