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Tolebrutinib

Chemical Structure : Tolebrutinib

CAS No.: 1971920-73-6

Tolebrutinib (PRN2246, SAR442168, BTK168)

Catalog No.: PC-38193Not For Human Use, Lab Use Only.

Tolebrutinib (PRN2246, SAR442168, BTK168) is a potent, selective oral brain-penetrant BTK inhibitor with IC50 of 0.4 and 0.7 nM in Ramos B cells and in HMC microglia cells, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Tolebrutinib (PRN2246, SAR442168, BTK168) is a potent, selective oral brain-penetrant BTK inhibitor with IC50 of 0.4 and 0.7 nM in Ramos B cells and in HMC microglia cells, respectively.
Tolebrutinib demonstrates potential immunomodulatory and anti-inflammatory activities, reduced new active brain lesions on MRI in people with relapsing multiple sclerosis (MS) in clinical investigation.

Physicochemical Properties

M.Wt 455.518
Formula C26H25N5O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

4-amino-3-(4-phenoxyphenyl)-1-[(3R)-1-prop-2-enoylpiperidin-3-yl]imidazo[4,5-c]pyridin-2-one

References

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