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Chemical Structure : Tolebrutinib
CAS No.: 1971920-73-6
Catalog No.: PC-38193Not For Human Use, Lab Use Only.
Tolebrutinib (PRN2246, SAR442168, BTK168) is a potent, selective oral brain-penetrant BTK inhibitor with IC50 of 0.4 and 0.7 nM in Ramos B cells and in HMC microglia cells, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $128 | In stock | |
| 25 mg | $218 | In stock | |
| 50 mg | $358 | In stock | |
| 100 mg | Get quote |
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Tolebrutinib (PRN2246, SAR442168, BTK168) is a potent, selective oral brain-penetrant BTK inhibitor with IC50 of 0.4 and 0.7 nM in Ramos B cells and in HMC microglia cells, respectively.
Tolebrutinib demonstrates potential immunomodulatory and anti-inflammatory activities, reduced new active brain lesions on MRI in people with relapsing multiple sclerosis (MS) in clinical investigation.
| M.Wt | 455.518 | |
| Formula | C26H25N5O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
4-amino-3-(4-phenoxyphenyl)-1-[(3R)-1-prop-2-enoylpiperidin-3-yl]imidazo[4,5-c]pyridin-2-one |
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1. Dahl K, et al. J Labelled Comp Radiopharm. 2020 Sep;63(11):482-487.
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