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Tolvaptan

Chemical Structure : Tolvaptan

CAS No.: 150683-30-0

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Tolvaptan (OPC41061, OPC-41061)

Catalog No.: PC-45125Not For Human Use, Lab Use Only.

Tolvaptan (OPC-41061) is a highly potent selective, competitive vasopressin V2-receptor antagonist with Ki of 0.43 nM, >200-fold more selective than for V1A-receptors.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Tolvaptan (OPC-41061) is a highly potent selective, competitive vasopressin V2-receptor antagonist with Ki of 0.43 nM, >200-fold more selective than for V1A-receptors.
Tolvaptan (OPC-41061) inhibits cAMP production induced by AVP with no intrinsic agonist activity.
Tolvaptan (OPC-41061) clearly produces dose-dependent aquaresis in rats.
Tolvaptan (OPC-41061) is orally active.

Physicochemical Properties

M.Wt 448.9413
Formula C26H25ClN2O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

Benzamide, N-[4-[(7-chloro-2,3,4,5-tetrahydro-5-hydroxy-1H-1-benzazepin-1-yl)carbonyl]-3-methylphenyl]-2-methyl-

References

1. Yamamura Y, et al. J Pharmacol Exp Ther. 1998 Dec;287(3):860-7.

2. Kondo K, et al. Bioorg Med Chem. 1999 Aug;7(8):1743-54.

3. Miyazaki T, et al. Endocrinology. 2005 Jul;146(7):3037-43.

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