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Toreforant

Chemical Structure : Toreforant

CAS No.: 952494-46-1

Toreforant (JNJ-38518168, JNJ38518168)

Catalog No.: PC-63399Not For Human Use, Lab Use Only.

Toreforant (JNJ-38518168) is a potent, selective histamine H4 receptor (H4R) antagonist with Ki of 8.4 nM, shows excellent selectivity over other receptors including the other histamine receptors.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Toreforant (JNJ-38518168) is a potent, selective histamine H4 receptor (H4R) antagonist with Ki of 8.4 nM, shows excellent selectivity over other receptors including the other histamine receptors.
Toreforant (JNJ-38518168) acts as an antagonist in all species tested and inhibits histamine-induced eosinophil shape change in vitro.
Toreforant (JNJ-38518168) demonstrates anti-inflammatory activities in mouse models of asthma and arthritis.

Physicochemical Properties

M.Wt 392.551
Formula C23H32N6
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

5-(4,6-dimethyl-1H-benzimidazol-2-yl)-4-methyl-N-[3-(1-methylpiperidin-4-yl)propyl]pyrimidin-2-amine

References

1. Thurmond RL, et al. J Rheumatol. 2016 Sep;43(9):1637-42.

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