 
                Chemical Structure : Toreforant
CAS No.: 952494-46-1
Catalog No.: PC-63399Not For Human Use, Lab Use Only.
Toreforant (JNJ-38518168) is a potent, selective histamine H4 receptor (H4R) antagonist with Ki of 8.4 nM, shows excellent selectivity over other receptors including the other histamine receptors.
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	Toreforant (JNJ-38518168) is a potent, selective histamine H4 receptor (H4R) antagonist with Ki of 8.4 nM, shows excellent selectivity over other receptors including the other histamine receptors.
	Toreforant (JNJ-38518168) acts as an antagonist in all species tested and inhibits histamine-induced eosinophil shape change in vitro.
	Toreforant (JNJ-38518168) demonstrates anti-inflammatory activities in mouse models of asthma and arthritis.
| M.Wt | 392.551 | |
| Formula | C23H32N6 | |
| Appearance | Solid | |
| Storage | 
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| Solubility | 10 mM in DMSO | |
| Chemical Name/SMILES | 5-(4,6-dimethyl-1H-benzimidazol-2-yl)-4-methyl-N-[3-(1-methylpiperidin-4-yl)propyl]pyrimidin-2-amine | |
1. Thurmond RL, et al. J Rheumatol. 2016 Sep;43(9):1637-42.

 
                 
                 
                 
                 
                 
                 
                 
                 
            
            
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