Catalog No.: PC-70071Not For Human Use, Lab Use Only.
Tosedostat (CHR-2797, CHR2797) is a potent, orally bioavailable aminopeptidases inhibitor with IC50 of 150, 220 and 100 nM for PuSA, aminopeptidase N and leucine aminopeptidase, respectively.
Tosedostat (CHR-2797, CHR2797) is a potent, orally bioavailable aminopeptidases inhibitor with IC50 of 150, 220 and 100 nM for PuSA, aminopeptidase N and leucine aminopeptidase, respectively.
Tosedostat (CHR-2797) exerts antiproliferative effects against a range of tumor cell lines in vitro and in vivo and shows selectivity for transformed over nontransformed cells.
Tosedostat (CHR-2797) inhibits phosphorylation of mTOR substrates and reduces protein synthesis in HL-60 cells.
