Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : Tovorafenib
CAS No.: 1096708-71-2
Catalog No.: PC-73449Not For Human Use, Lab Use Only.
Tovorafenib (MLN2480, TAK-580) is potent, selective, brain-penetrant RAF dimer antagonist, inhibits MAP kinase pathway signaling in BRAF-mutant melanoma models.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $98 | In stock | |
| 10 mg | $148 | In stock | |
| 25 mg | $258 | In stock | |
| 50 mg | $428 | In stock | |
| 100 mg | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Tovorafenib (MLN2480, TAK-580) is potent, selective, brain-penetrant RAF dimer antagonist, inhibits MAP kinase pathway signaling in BRAF-mutant melanoma models.
MLN2480 can cross the blood–brain barrier and retard growth of BRAFV600E and KIAA1549:BRAF intracranial tumors in NCr-NU mice.
MLN2480 retarded the growth of both of both BRAFV600E and KIAA1549:BRAF-driven tumors and increased survival of the treated mice.
MLN2480 is an equipotent inhibitor of catalysis in BRAF monomers and dimers.
| M.Wt | 506.3 | |
| Formula | C17H12Cl2F3N7O2S | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
(R)-2-(1-(6-Amino-5-chloropyrimidine-4-carboxamido)ethyl)-N-(5-chloro-4-(trifluoromethyl)pyridin-2-yl)thiazole-5-carboxamide |
|
1. Sun Y, et al. Neuro Oncol. 2017 Jun 1;19(6):774-785.
2. Gampa G, et al. J Pharmacol Exp Ther. 2019 Mar;368(3):446-461.
3. Suzuki R, et al. Int J Hematol. 2022 Feb;115(2):233-243.
4. Samatar AA, et al. Nat Rev Drug Discov. 2014; 13(12):928-942.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
