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Chemical Structure : Tpl2-2
Catalog No.: PC-22729Not For Human Use, Lab Use Only.
Tpl2-2 (TPL2 Kinase Inhibitor II) is a cell-permeable naphthyridine-cyclohexyl Tpl2-1 analog that acts as a potent ATP-competitive Tpl2 inhibitor (IC50 =160 nM).
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Tpl2-2 (TPL2 Kinase Inhibitor II) is a cell-permeable naphthyridine-cyclohexyl Tpl2-1 analog that acts as a potent ATP-competitive Tpl2 inhibitor (IC50 =160 nM).
Tpl2-2 shows little activity (IC50 >20 μM) against EGFR, Src, MEK, p38, PKA, PKC, or S6.
Tpl2-2 blocks LPS-induced TNF-α production both in vitro (IC50 = 0.5 and 4.5 μM using human monocytes and whole blood, respectively) and in rats in vivo (10 mg/kg, i.p.).
| M.Wt | 390.49 | |
| Formula | C22H26N6O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Neelu Kaila, et al. Bioorg Med Chem. 2007 Oct 1;15(19):6425-42.
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