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Chemical Structure : Tpl2/MAP3K8 inhibitor 32
Catalog No.: PC-22733Not For Human Use, Lab Use Only.
Tpl2/MAP3K8 inhibitor 32 is a potent, selective inhibitor of cancer osaka thyroid (COT) kinase (Tpl2, MAP3K8) with IC50 of 6 nM.
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Tpl2/MAP3K8 inhibitor 32 is a potent, selective inhibitor of cancer osaka thyroid (COT) kinase (Tpl2, MAP3K8) with IC50 of 6 nM.
Tpl2/MAP3K8 inhibitor 32 inhibits pERK and TNFα production in PBMCs with IC50 of 60 nM for both.
Tpl2/MAP3K8 inhibitor 32 demonstrates potent inhibition of the formation of the pro-inflammatory cytokine interleukin-1β (IC50: 0.2 μM) in uric-acid, stimulated macrophages.
Tpl2/MAP3K8 inhibitor 32 (5-15 mg/kg) shows a clear amelioration of inflammatory events in the dog uric acid-induced synovitis model.
| M.Wt | 516.61 | |
| Formula | C30H28N8O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Ralf Glatthar, et al. J Med Chem. 2016 Aug 25;59(16):7544-60.
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