Trabectedin |CAS:114899-77-3 Probechem Biochemicals

Chemical Structure : Trabectedin

CAS No.: 114899-77-3

Trabectedin (Ecteinascidin-743, ET-743, Ecteinascidin)

Catalog No.: PC-45909Not For Human Use, Lab Use Only.

Trabectedin (Ecteinascidin-743, ET-743, Ecteinascidin) is a marine alkaloid isolated from the Caribbean tunicate Ecteinascidia turbinata that shows remarkably anticancer activity in a variety of in vitro and in vivo systems.

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Biological Activity

Trabectedin (Ecteinascidin-743, ET-743, Ecteinascidin) is a marine alkaloid isolated from the Caribbean tunicate Ecteinascidia turbinata that shows remarkably anticancer activity in a variety of in vitro and in vivo systems.
Trabectedin is a DNA minor groove, guanine-specific alkylating agent.
Trabectedin shows high potency against ovarian carcinoma xenografts.

Physicochemical Properties

M.Wt	761.8372
Formula	C39H43N3O11S
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Spiro[6,16-(epithiopropanoxymethano)-7,13-imino-12H-1,3-dioxolo[7,8]isoquino[3,2-b][3]benzazocine-20,1'(2'H)-isoquinolin]-19-one, 5-(acetyloxy)-3',4',6,6a,7,13,14,16-octahydro-6',8,14-trihydroxy-7',9-dimethoxy-4,10,23-trimethyl-, (1'R,6R,6aR,7R,13S,14S,16

References

1. Pommier Y, et al. Biochemistry. 1996 Oct 15;35(41):13303-9.

2. Valoti G, et al. Clin Cancer Res. 1998 Aug;4(8):1977-83.

Trabectedin (Ecteinascidin-743, ET-743, Ecteinascidin)

Biological Activity

Physicochemical Properties

References

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