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Chemical Structure : Traxoprodil mesylate
Catalog No.: PC-61515Not For Human Use, Lab Use Only.
A potent, selective N-methyl-D-aspartate (NMDA) antagonist with selectivity for the NR2B subunit.
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A potent, selective N-methyl-D-aspartate (NMDA) antagonist with selectivity for the NR2B subunit; potently protects cultured hippocampal neurons from glutamate toxicity (IC50=10 nM), dramatically reduces both the open dwell-time and frequency of channel opening of NR1/NR2B-containing receptors, but only modestly inhibits NR1/NR2A and NR1/NR2C channel activity; exhibits neuroprotective, analgesic, and anti-Parkinsonian effects in animal studies.
Depression
Phase 2 Discontinued
| M.Wt | 423.524 | |
| Formula | C21H29NO6S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Chenard BL, et al. J Med Chem. 1995 Aug 4;38(16):3138-45.
2. Taniguchi K, et al. Br J Pharmacol. 1997 Nov;122(5):809-12.
3. Brimecombe JC, et al. Proc Natl Acad Sci U S A. 1997 Sep 30;94(20):11019-24.
4. Guscott MR, et al. Eur J Pharmacol. 2003 Aug 29;476(3):193-9.
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