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Trequinsin hydrochloride

Chemical Structure : Trequinsin hydrochloride

CAS No.: 78416-81-6

Trequinsin hydrochloride (HL 725)

Catalog No.: PC-62884Not For Human Use, Lab Use Only.

Trequinsin hydrochloride (HL 725) is a potent, cell-permeable, orally active inhibitor of cGMP-inhibited phosphodiesterase (PCE3 IC50=250 pM), inhibits arachidonic acid-induced aggregation of human platelets with IC50 of 50 pM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Trequinsin hydrochloride (HL 725) is a potent, cell-permeable, orally active inhibitor of cGMP-inhibited phosphodiesterase (PCE3 IC50=250 pM), inhibits arachidonic acid-induced aggregation of human platelets with IC50 of 50 pM; reduces systemic blood pressure in both normotensive and hypertensive animal models.

Hypertension

Discontinued

Physicochemical Properties

M.Wt 441.956
Formula C24H28ClN3O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

2,3,6,7-Tetrahydro-9,10-dimethoxy-3-methyl-2-[(2,4,6-trimethylphenyl)imino]-4H-pyrimido[6,1-a]isoquinolin-4-one hydrochloride

References

1. Lal B, et al. J Med Chem. 1984 Nov;27(11):1470-80.

2. Ruppert D, et al. Life Sci. 1982 Nov 8;31(19):2037-43.

3. Darius H, et al. Br J Pharmacol. 1985 Mar;84(3):735-41.

4. Blaskó G, et al. Thromb Res. 1986 Jul 15;43(2):249-50.

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