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Trequinsin hydrochloride

Chemical Structure : Trequinsin hydrochloride

CAS No.: 78416-81-6

Trequinsin hydrochloride (HL 725)

Catalog No.: PC-62884Not For Human Use, Lab Use Only.

Trequinsin hydrochloride (HL 725) is a potent, cell-permeable, orally active inhibitor of cGMP-inhibited phosphodiesterase (PDE3 IC50=250 pM), inhibits arachidonic acid-induced aggregation of human platelets with IC50 of 50 pM.

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Biological Activity

Trequinsin hydrochloride (HL 725) is a potent, cell-permeable, orally active inhibitor of cGMP-inhibited phosphodiesterase (PDE3 IC50=250 pM), inhibits arachidonic acid-induced aggregation of human platelets with IC50 of 50 pM.
Trequinsin reduces systemic blood pressure in both normotensive and hypertensive animal models.

Physicochemical Properties

M.Wt 441.956
Formula C24H28ClN3O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

2,3,6,7-Tetrahydro-9,10-dimethoxy-3-methyl-2-[(2,4,6-trimethylphenyl)imino]-4H-pyrimido[6,1-a]isoquinolin-4-one hydrochloride

References

1. Lal B, et al. J Med Chem. 1984 Nov;27(11):1470-80.

2. Ruppert D, et al. Life Sci. 1982 Nov 8;31(19):2037-43.

3. Darius H, et al. Br J Pharmacol. 1985 Mar;84(3):735-41.

4. Blaskó G, et al. Thromb Res. 1986 Jul 15;43(2):249-50.

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