Trifluoperazine dihydrochloride |CAS:440-17-5 Probechem Biochemicals

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Chemical Structure : Trifluoperazine dihydrochloride

CAS No.: 440-17-5

Trifluoperazine dihydrochloride (TFP;SKF5019)

Catalog No.: PC-46699Not For Human Use, Lab Use Only.

An antiadrenergic, antidopaminergic and anticholinergic agent.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

An antiadrenergic, antidopaminergic and anticholinergic agent; is identified as an inhibitor that disrupts the S100A4/myosin-IIA interaction; block S100A4-mediated disassembly of myosin-IIA filaments, and promote S100A4 oligomerization.

Schizophrenia

Approved

Physicochemical Properties

M.Wt	480.4174
Formula	C21H26Cl2F3N3S
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	10H-Phenothiazine, 10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoromethyl)-, hydrochloride (1:2)

References

1. Malashkevich VN, et al. Proc Natl Acad Sci U S A. 2010 May 11;107(19):8605-10.

2. Huerta-Bahena J, et al. Mol Pharmacol. 1983 Jan;23(1):67-70.

3. Creese I, et al. J Neuropsychiatry Clin Neurosci. 1996 Spring;8(2):223-6.

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Trifluoperazine dihydrochloride (TFP;SKF5019)

Biological Activity

Physicochemical Properties

References

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